Virus B and Abelton Live

First of all you need to have a way of sending MIDI out of your computer and a way of getting audio back in - most modern audio interfaces should do. Connect the Virus MIDI in to one of the interface's MIDI outs, and the Virus main audio out to one of the interface's audio in (both L and R for stereo). Now on a new track in Ableton Live insert an external MIDI plugin (it's a stock plugin). Configure the plugin to use the interface's Audio and MIDI ports which are connected to the Virus. Note that this plugin cannot be frozen.
Good luck!

In the Live Devices browser - it's called External Instrument.