Well I just got my Christmas present.
http://www.solar3d-software.com just created a Standalone app for macOS Big Sur.
Works beautifully on my M1 Mac Air using the Roland UM-ONE.
Solar3d Standalone app for Big Sur and TI2
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I've tried this but how can you work with this? the GUI is completely random!
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Turn a knob on the hardware and the pages turn automatically.
VirusHC and the CTRLR panels do that too.. Just a better GUI. The CTRLR panel is actually an exact copy of the Virus TI plugin.. I would use it if it had support for multi mode. That's why I chose VirusHC.
So what makes Solar3d so good? Genuinely curious.