I can have the USB port to control the presets (MacBook Pro with VirusHC) and the two MIDI ports to be connected to other hardware, Toraiz Squid, Analog Rytm MKII, Nord Modular, MiniBrute, etc, without depending on a computer?
This would really be the ideal.
You can certainly control presets on USB and use the MIDI ports to send and receive to/from external devices. However, if you have USB connected, the Virus *synth* engine won't receive MIDI on the 5 pin DIN MIDI input. In that case, you have to send MIDI notes etc. to the Virus via USB.
That is a shame indeed.