First thanks for any suggestions that were posted.
After careful testing, contact with Access support, and contact with Apple support I can confirm that there is an issue with High Sierra and the audio dropping out on my system.
First, there is a known issue with running external monitors in High Sierra and even thought Access support claims that external monitors have no impact on their interface, after numerious testing with my external monitors I have found that the drop outs increase and the sound becomes distorted on occasion. Considering the monitors and the Virus are all on the same bus, something is going on.
I tried a fresh install and once again after plugging in my external monitors, audio dropped.
I went back to Sierra and the system has been rock solid. I will stay with Sierra until I hear that Apple has addressed the monitor issue and hopefully that will address the audio droop outs as well. If anyone comes across any issue like this let me know.
I will update as needed.