Reverted back to 4.05 and it seems to not crash Cubase anymore. However, I definately worked on a track in February, where the Virus was playing a large role and I worked with 4.1 and had no issues.
If the Virus is turned off and I open and close the VCC 4.5 /4.1, no crash happens. So it's not the VCC itself.
Let's check it on different versions of Windows.