One small extra question to this topic:
S/PDIF seems to work nice for me. However, I get some clicks now and then, not frequent at all, but they do occur, maybe once or twice in a 3-4 minute long track. Also when I bounce I still have one-two clicks in my exports. I did not have those using the analog outs.
Any idea what could be wrong and how I could fix this?
Do you have your interface's clock source set to S/PDIF? If not that could be the issue.
Also, on the topic of the audio being identical up to the point it either gets passed through as digital or converted to analog..... if memory serves, the well documented issue of unintentional slight pitch oscillation doesn't occur when using analog outs. Personally I just restart my DAW and Virus before recording to help get smooth operation from it and stick to USB outs