From the TI Setup Guide
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Audio Side-chaining
“Side-chaining” means to feed audio from one device into another, bypassing the
actual audio inputs. For us, it means that you can send audio from your sequencer
into Virus Control (and therefore the Virus hardware), mangle with it, and then send
it back.
In order to use side-chaining, you need to enable the “3 Outputs / 1 Input” mode in
Virus Control’s settings first. Please note that once this mode is enabled, the Virus
cannot double as a soundcard anymore. Also, please note that, at the time of
writing, the side-chaining implementation of some sequencers is either non-existent
or faulty. Steinberg Cubase for instance does not support it at all for virtual
instruments and, at the time of writing, Apple Logic has an issue which results in a
delayed audio signal at the side-chain input.
It seems that Logic has an issue with side-chain....For my part, I'm with Cakewalk Sonar, and I can't use Sidechain too....the USB Virus input doesn't appear anywhere...the only solution is to route your guitar track toward a physical output of your audio interface, and then connect this output to the physical input of the virus...finally set up the Virus to have the physical input as the source of ext sounds (not USB).....but be carefull with latency...