The Virus seems to be working fine on Yosemite 10.10 for me using Virus TI 5.0.8.00 for Mac OS X. I did have to reinstall 5.0.8.00, but after the reinstall everything seems stable so far.
Quite frankly I didn't think my Virus would work, so I'm pretty happy at this point. Obviously, this is just one system, an iMac, and one user's limited testing so far. I'll update here if I run into any issues.
