So okiedokie, I downloaded the OTT and was able to reproduce the artefacts / "bugging". Its has really nothing to do with Virus TI, just plain and simple output levels. <- the reason why a different vst might not produce the artefacts and the virus will, or via versa. They differ and it seems OTT is particularly "sensitive" to that, youll need just a tiny nugde of too much input gain, and the thing will flip and starts to produce really annoying sounding artefacts. This will happen regardless from what you input to the OTT. Even a rendered "perfect" 256 samples long sinewave did the same thing (and there really is not any "noise" etc in that) , so its not USB noise nor any of the suggested above.
Just adjust the input gain from the OTT to more suitable level, and you are free from the artefacts (play your stuff at full velocity and adjust the input gain from OTT until the artefacts are gone)
Now, thers more weirdness to the OTT and regarding midi velocities, it is a really weird plugin have to say that. Only other FX I could get similar artefacts was a distortion
with insane amount of gain, I had to use several plugins to crank it up enough.
Hope that helps.