Hi I just booted up OSX now and tested it with LOGIC and there is no issues at all with any of the crackling sounds. I will attempt the instructions now and see if that fixes it in the installation folder.
EDIT I have done the uninstall as instructed in the folder and it is still the same and my driver version shows as 2.8.45 in device manager. Here is an example of the sound I get from my virus its a standard saw lead and a simple midi loaded https://dl.dropbox.com/u/6091004/Virus%20TI%20sound.mp3