I’d start with a square wave on both OSC and OSC sync. OSC at least one octave apart and some detune. Or some FM. Or a detuned Hypersaw. Add unison or chorus. A good deal of distortion (e.g. carefully tuned sine fold) for added scream. A touch of delay and reverb to add bigness. Use LFOs or Envelopes to modulate pitch and detune.
This is where all the fun starts on the Virus.